4iik: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Legionella pneumophila effector===

~~The entry 4iik~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/SIDD_LEGPH SIDD_LEGPH]] Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as an adenosine monophosphate-protein hydrolase (de-AMPylase) by mediating the hydrolysis of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby releasing RAB1B from bacterial phagosomes and rendering RAB1B accessible for inactivation by LepB. De-AMPylation of RAB1B cannot take place when LidA is bound to RAB1B.<ref>PMID:21734656</ref> <ref>PMID:21680813</ref> <ref>PMID:22228731</ref>

~~Authors~~: ~~Tascon, I~~.~~, Chen, Y~~.~~, Neunuebel, M~~.R.~~, Rojas, A~~.L.~~, Machner, M~~.P.~~, Hierro, A~~.

==About this Structure==

[[4iik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._philadelphia_1 Legionella pneumophila subsp. pneumophila str. philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIK OCA].

~~Description~~: Legionella pneumophila ~~effector~~

==Reference==

[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]]

[[Category: Chen, Y.]]

[[Category: Hierro, A.]]

[[Category: Machner, M P.]]

[[Category: Neunuebel, M R.]]

[[Category: Rojas, A L.]]

[[Category: Tascon, I.]]

[[Category: Beta sandwich]]

[[Category: De-ampylation]]

[[Category: Hydrolase]]

[[Category: Legionella containing vacuole surface]]

[[Category: Rab1]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4iik|  PDB=4iik  |  SCENE=  }}
+===Legionella pneumophila effector===
+{{ABSTRACT_PUBMED_23696742}}
-The entry 4iik is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/SIDD_LEGPH SIDD_LEGPH]] Virulence effector that plays a role in hijacking the host vesicular trafficking by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole (LCVs). Acts as an adenosine monophosphate-protein hydrolase (de-AMPylase) by mediating the hydrolysis of adenosine 5'-monophosphate (AMP) to 'Tyr-77' of host RAB1B, thereby releasing RAB1B from bacterial phagosomes and rendering RAB1B accessible for inactivation by LepB. De-AMPylation of RAB1B cannot take place when LidA is bound to RAB1B.<ref>PMID:21734656</ref> <ref>PMID:21680813</ref> <ref>PMID:22228731</ref>
-Authors: Tascon, I., Chen, Y., Neunuebel, M.R., Rojas, A.L., Machner, M.P., Hierro, A.
+==About this Structure==
+[[4iik]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._philadelphia_1 Legionella pneumophila subsp. pneumophila str. philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IIK OCA].
-Description: Legionella pneumophila effector
+==Reference==
+<ref group="xtra">PMID:023696742</ref><references group="xtra"/><references/>
+[[Category: Legionella pneumophila subsp. pneumophila str. philadelphia 1]]
+[[Category: Chen, Y.]]
+[[Category: Hierro, A.]]
+[[Category: Machner, M P.]]
+[[Category: Neunuebel, M R.]]
+[[Category: Rojas, A L.]]
+[[Category: Tascon, I.]]
+[[Category: Beta sandwich]]
+[[Category: De-ampylation]]
+[[Category: Hydrolase]]
+[[Category: Legionella containing vacuole surface]]
+[[Category: Rab1]]