4gv7: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328===

~~The entry 4gv7~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

~~Authors~~: ~~Karlberg, T~~.~~, Thorsell, A~~.G.~~, Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J~~.~~, Linusson, A~~.~~, Elofsson, M~~.~~, Schuler, H~~.

==About this Structure==

[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA].

~~Description~~: ~~Human ARTD1 (PARP1)~~ -~~Catalytic~~ domain in complex ~~with inhibitor ME0328~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Andersson, C D.]]

[[Category: Ekblad, T.]]

[[Category: Elofsson, M.]]

[[Category: Karlberg, T.]]

[[Category: Lindgren, A E.G.]]

[[Category: Linusson, A.]]

[[Category: Schuler, H.]]

[[Category: Spjut, S.]]

[[Category: Thorsell, A G.]]

[[Category: Weigelt, J.]]

[[Category: Adp-ribose]]

[[Category: Adp-ribose transferase]]

[[Category: Adp-ribosylation]]

[[Category: Artd transferase domain]]

[[Category: Artd1]]

[[Category: Nad]]

[[Category: Parp1]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4gv7|  PDB=4gv7  |  SCENE=  }}
+===Human ARTD1 (PARP1) - Catalytic domain in complex with inhibitor ME0328===
+{{ABSTRACT_PUBMED_23742272}}
-The entry 4gv7 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
-Authors: Karlberg, T., Thorsell, A.G., Lindgren, A.E.G., Ekblad, T., Spjut, S., Andersson, C.D., Weigelt, J., Linusson, A., Elofsson, M., Schuler, H.
+==About this Structure==
+[[4gv7]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GV7 OCA].
-Description: Human ARTD1 (PARP1) -Catalytic domain in complex with inhibitor ME0328
+==Reference==
+<ref group="xtra">PMID:023742272</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Andersson, C D.]]
+[[Category: Ekblad, T.]]
+[[Category: Elofsson, M.]]
+[[Category: Karlberg, T.]]
+[[Category: Lindgren, A E.G.]]
+[[Category: Linusson, A.]]
+[[Category: Schuler, H.]]
+[[Category: Spjut, S.]]
+[[Category: Thorsell, A G.]]
+[[Category: Weigelt, J.]]
+[[Category: Adp-ribose]]
+[[Category: Adp-ribose transferase]]
+[[Category: Adp-ribosylation]]
+[[Category: Artd transferase domain]]
+[[Category: Artd1]]
+[[Category: Nad]]
+[[Category: Parp1]]
+[[Category: Transferase-transferase inhibitor complex]]