4jgc: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)===

~~The entry 4jgc~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.

~~Authors~~: ~~Hashimoto, H~~.~~, Zhang, X~~.~~, Cheng, X~~.

==About this Structure==

[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA].

~~Description~~: ~~Human TDG N140A mutant IN A COMPLEX WITH~~ 5-carboxylcytosine ~~(5caC)~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Thymine-DNA glycosylase]]

[[Category: Cheng, X.]]

[[Category: Hashimoto, H.]]

[[Category: Zhang, X.]]

[[Category: 5-carboxylcytosine]]

[[Category: Dna 5mc oxidation]]

[[Category: Dna demethylation]]

[[Category: Dna modification]]

[[Category: Epigenetic regulation]]

[[Category: Hydrolase-dna complex]]

[[Category: Thymine dna glycosylase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4jgc|  PDB=4jgc  |  SCENE=  }}
+===Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)===
+{{ABSTRACT_PUBMED_23680598}}
-The entry 4jgc is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/TDG_HUMAN TDG_HUMAN]] In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
-Authors: Hashimoto, H., Zhang, X., Cheng, X.
+==About this Structure==
+[[4jgc]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JGC OCA].
-Description: Human TDG N140A mutant IN A COMPLEX WITH 5-carboxylcytosine (5caC)
+==Reference==
+<ref group="xtra">PMID:023680598</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Thymine-DNA glycosylase]]
+[[Category: Cheng, X.]]
+[[Category: Hashimoto, H.]]
+[[Category: Zhang, X.]]
+[[Category: 5-carboxylcytosine]]
+[[Category: Dna 5mc oxidation]]
+[[Category: Dna demethylation]]
+[[Category: Dna modification]]
+[[Category: Epigenetic regulation]]
+[[Category: Hydrolase-dna complex]]
+[[Category: Thymine dna glycosylase]]