2hfp: Difference between revisions
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New page: left|200px<br /> <applet load="2hfp" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hfp, resolution 2.000Å" /> '''Crystal Structure ... |
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[[Image:2hfp.gif|left|200px]]<br /> | [[Image:2hfp.gif|left|200px]]<br /><applet load="2hfp" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2hfp" size=" | |||
caption="2hfp, resolution 2.000Å" /> | caption="2hfp, resolution 2.000Å" /> | ||
'''Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands'''<br /> | '''Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands'''<br /> | ||
==Overview== | ==Overview== | ||
The synthesis and structure-activity relationships of a novel series of | The synthesis and structure-activity relationships of a novel series of N-sulfonyl-2-indole carboxamides that bind to peroxisome proliferator-activated receptor gamma (PPAR-gamma) are reported. Chemical optimization of the series led to the identification of 4q (IC(50)=50 nM) as a potent binding agent of PPAR-gamma. Also reported is preliminary cell based data suggesting the use of these compounds in the treatment of osteoporosis. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
2HFP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NSI as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 2HFP is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NSI:'>NSI</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HFP OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Evdokimov, A | [[Category: Evdokimov, A G.]] | ||
[[Category: Hopkins, C | [[Category: Hopkins, C R.]] | ||
[[Category: Mekel, M | [[Category: Mekel, M J.]] | ||
[[Category: Pokross, M | [[Category: Pokross, M E.]] | ||
[[Category: Walter, R | [[Category: Walter, R L.]] | ||
[[Category: NSI]] | [[Category: NSI]] | ||
[[Category: ppar ppargamma lbd]] | [[Category: ppar ppargamma lbd]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:41:21 2008'' | ||
