4g4e: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the L88A mutant of HslV from Escherichia coli===

The ~~entry 4g4e~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/HSLV_ECOLI HSLV_ECOLI]] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref>

~~Authors~~: ~~Lee, J~~.W.~~, Park, E, Yoo, H~~.~~M., Ha, B.H., An, J.Y., Jeon, Y.J., Seol, J.H., Eom, S~~.H.~~, Chung, C~~.H.

==About this Structure==

[[4g4e]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4E OCA].

~~Description~~: ~~Crystal structure of the L88A mutant of HslV from~~ Escherichia coli

==Reference==

[[Category: Escherichia coli k-12]]

[[Category: HslU--HslV peptidase]]

[[Category: An, J Y.]]

[[Category: Chung, C H.]]

[[Category: Eom, S H.]]

[[Category: Ha, B H.]]

[[Category: Jeon, Y J.]]

[[Category: Lee, J W.]]

[[Category: Park, E]]

[[Category: Seol, J H.]]

[[Category: Yoo, H M.]]

[[Category: Atp-dependent protease]]

[[Category: Hslu atpase]]

[[Category: Hslv protease]]

[[Category: Hslvu]]

[[Category: Hydrolase]]

[[Category: Pore motif]]

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-'''Unreleased structure'''
+{{STRUCTURE_4g4e|  PDB=4g4e  |  SCENE=  }}
+===Crystal structure of the L88A mutant of HslV from Escherichia coli===
+{{ABSTRACT_PUBMED_23707406}}
-The entry 4g4e is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/HSLV_ECOLI HSLV_ECOLI]] Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.<ref>PMID:8662828</ref> <ref>PMID:8650174</ref> <ref>PMID:9288941</ref> <ref>PMID:9393683</ref> <ref>PMID:10452560</ref> <ref>PMID:10419524</ref> <ref>PMID:15696175</ref>
-Authors: Lee, J.W., Park, E, Yoo, H.M., Ha, B.H., An, J.Y., Jeon, Y.J., Seol, J.H., Eom, S.H., Chung, C.H.
+==About this Structure==
+[[4g4e]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G4E OCA].
-Description: Crystal structure of the L88A mutant of HslV from Escherichia coli
+==Reference==
+<ref group="xtra">PMID:023707406</ref><references group="xtra"/><references/>
+[[Category: Escherichia coli k-12]]
+[[Category: HslU--HslV peptidase]]
+[[Category: An, J Y.]]
+[[Category: Chung, C H.]]
+[[Category: Eom, S H.]]
+[[Category: Ha, B H.]]
+[[Category: Jeon, Y J.]]
+[[Category: Lee, J W.]]
+[[Category: Park, E]]
+[[Category: Seol, J H.]]
+[[Category: Yoo, H M.]]
+[[Category: Atp-dependent protease]]
+[[Category: Hslu atpase]]
+[[Category: Hslv protease]]
+[[Category: Hslvu]]
+[[Category: Hydrolase]]
+[[Category: Pore motif]]