2m17: Difference between revisions
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{{STRUCTURE_2m17| PDB=2m17 | SCENE= }} | |||
===ubiquitin-like domain-containing C-terminal domain phosphatase (UBLCP1)=== | |||
{{ABSTRACT_PUBMED_23667555}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/UBCP1_HUMAN UBCP1_HUMAN]] Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.<ref>PMID:15883030</ref> <ref>PMID:21949367</ref> | |||
==About this Structure== | |||
[[2m17]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M17 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023667555</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Phosphoprotein phosphatase]] | |||
[[Category: Lee, W.]] | |||
[[Category: Yun, J.]] | |||
[[Category: Hydrolase]] | |||
Revision as of 17:54, 19 June 2013
ubiquitin-like domain-containing C-terminal domain phosphatase (UBLCP1)
Template:ABSTRACT PUBMED 23667555
Function
[UBCP1_HUMAN] Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.[1] [2]
About this Structure
2m17 is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Yun JH, Ko S, Lee CK, Cheong HK, Cheong C, Yoon JB, Lee W. Solution Structure and Rpn1 Interaction of the UBL Domain of Human RNA Polymerase II C-Terminal Domain Phosphatase. PLoS One. 2013 May 7;8(5):e62981. doi: 10.1371/journal.pone.0062981. Print 2013. PMID:23667555 doi:10.1371/journal.pone.0062981
- ↑ Zheng H, Ji C, Gu S, Shi B, Wang J, Xie Y, Mao Y. Cloning and characterization of a novel RNA polymerase II C-terminal domain phosphatase. Biochem Biophys Res Commun. 2005 Jun 17;331(4):1401-7. PMID:15883030 doi:S0006-291X(05)00831-4
- ↑ Guo X, Engel JL, Xiao J, Tagliabracci VS, Wang X, Huang L, Dixon JE. UBLCP1 is a 26S proteasome phosphatase that regulates nuclear proteasome activity. Proc Natl Acad Sci U S A. 2011 Sep 26. PMID:21949367 doi:10.1073/pnas.1113170108
