2lwp: Difference between revisions
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{{STRUCTURE_2lwp| PDB=2lwp | SCENE= }} | |||
===The NMR solution structure of the the ubiquitin homology domain of mouse BAG-1=== | |||
{{ABSTRACT_PUBMED_23277101}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BAG1_MOUSE BAG1_MOUSE]] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9873016</ref> | |||
==About this Structure== | |||
[[2lwp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LWP OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023277101</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Huang, H.]] | |||
[[Category: Yu, C.]] | |||
[[Category: Apoptosis]] | |||
[[Category: Proteasomal degradation]] | |||
Revision as of 17:59, 19 June 2013
The NMR solution structure of the the ubiquitin homology domain of mouse BAG-1
Template:ABSTRACT PUBMED 23277101
Function
[BAG1_MOUSE] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.[1]
About this Structure
2lwp is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA.
Reference
- Huang HW, Yu C. The NMR solution structure of the ubiquitin homology domain of Bcl-2-associated athanogene 1 (BAG-1-UBH) from Mus musculus. Biochem Biophys Res Commun. 2013 Feb 1;431(1):86-91. doi:, 10.1016/j.bbrc.2012.12.082. Epub 2012 Dec 28. PMID:23277101 doi:10.1016/j.bbrc.2012.12.082
