2hkk: Difference between revisions

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==Overview==

The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), with L-adrenaline and histamine has been investigated by kinetic and X-ray, crystallographic studies. L-Adrenaline behaves as a potent activator of, isozyme CA I (activation constant of 90 nM), being a much weaker activator, of isozyme CA II (activation constant of 96 microM). Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of, 36-63 microM. The X-ray crystal structure of the CA II-L-adrenaline adduct, revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.

The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with L-adrenaline and histamine has been investigated by kinetic and X-ray crystallographic studies. L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM). Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of 36-63 microM. The X-ray crystal structure of the CA II-L-adrenaline adduct revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.

==Disease==

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611492 611492]]

==About this Structure==

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[[Category: Innocenti, A.]]

[[Category: Scozzafava, A.]]

[[Category: Supuran, C.T.]]

[[Category: Supuran, C T.]]

[[Category: Temperini, C.]]

[[Category: Vullo, D.]]

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[[Category: crystal structure]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1), with L-adrenaline and histamine has been investigated by kinetic and X-ray, crystallographic studies. L-Adrenaline behaves as a potent activator of, isozyme CA I (activation constant of 90 nM), being a much weaker activator, of isozyme CA II (activation constant of 96 microM). Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of, 36-63 microM. The X-ray crystal structure of the CA II-L-adrenaline adduct, revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.
+The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with L-adrenaline and histamine has been investigated by kinetic and X-ray crystallographic studies. L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM). Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of 36-63 microM. The X-ray crystal structure of the CA II-L-adrenaline adduct revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.
+==Disease==
+Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611492 611492]]
 ==About this Structure==
@@ Line 16: / Line 19: @@
 [[Category: Innocenti, A.]]
 [[Category: Scozzafava, A.]]
-[[Category: Supuran, C.T.]]
+[[Category: Supuran, C T.]]
 [[Category: Temperini, C.]]
 [[Category: Vullo, D.]]
@@ Line 26: / Line 29: @@
 [[Category: crystal structure]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 15:11:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:42:51 2008''