4ap8: Difference between revisions
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{{STRUCTURE_4ap8| PDB=4ap8 | SCENE= }} | {{STRUCTURE_4ap8| PDB=4ap8 | SCENE= }} | ||
===Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)=== | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN]] Molybdenum cofactor deficiency type B (MOCOD type B) [MIM:[http://omim.org/entry/252150 252150]]: Autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Note=The disease is caused by mutations affecting the gene represented in this entry. | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN]] Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.<ref>PMID:12732628</ref> <ref>PMID:15073332</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4ap8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA]. | [[4ap8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA]. | ||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Molybdopterin synthase]] | [[Category: Molybdopterin synthase]] | ||
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[[Category: Bountra, C.]] | [[Category: Bountra, C.]] | ||
[[Category: Burgess-Brown, N.]] | [[Category: Burgess-Brown, N.]] | ||
[[Category: Delft, F | [[Category: Delft, F von.]] | ||
[[Category: Edwards, A.]] | [[Category: Edwards, A.]] | ||
[[Category: Froese, D S.]] | [[Category: Froese, D S.]] | ||