4ap8: Difference between revisions

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[[Image:4ap8.png|left|200px]]
{{STRUCTURE_4ap8|  PDB=4ap8  |  SCENE=  }}  
{{STRUCTURE_4ap8|  PDB=4ap8  |  SCENE=  }}  
===Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)===


===Crystal structure of human Molybdopterin synthase catalytic subunit (MOCS2B)===
==Disease==
[[http://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN]] Molybdenum cofactor deficiency type B (MOCOD type B) [MIM:[http://omim.org/entry/252150 252150]]: Autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death. Note=The disease is caused by mutations affecting the gene represented in this entry.


==Function==
[[http://www.uniprot.org/uniprot/MOC2B_HUMAN MOC2B_HUMAN]] Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.<ref>PMID:12732628</ref> <ref>PMID:15073332</ref> 


==About this Structure==
==About this Structure==
[[4ap8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA].  
[[4ap8]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AP8 OCA].  
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Molybdopterin synthase]]
[[Category: Molybdopterin synthase]]
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[[Category: Bountra, C.]]
[[Category: Bountra, C.]]
[[Category: Burgess-Brown, N.]]
[[Category: Burgess-Brown, N.]]
[[Category: Delft, F Von.]]
[[Category: Delft, F von.]]
[[Category: Edwards, A.]]
[[Category: Edwards, A.]]
[[Category: Froese, D S.]]
[[Category: Froese, D S.]]