2lu3: Difference between revisions
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{{STRUCTURE_2lu3| PDB=2lu3 | SCENE= }} | |||
===Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/AAKB2_RAT AAKB2_RAT]] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity). | |||
==About this Structure== | |||
[[2lu3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LU3 OCA]. | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Gooley, P.]] | |||
[[Category: Koay, A.]] | |||
[[Category: Stapleton, D.]] | |||
[[Category: Carbohydrate binding module]] | |||
[[Category: Glycogen binding]] | |||
[[Category: Sugar binding protein]] | |||
Revision as of 21:00, 19 June 2013
Solution NMR structure of the apo-form of the beta2 carbohydrate module of AMP-activated protein kinase
Function
[AAKB2_RAT] Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3) (By similarity).
About this Structure
2lu3 is a 1 chain structure with sequence from Rattus norvegicus. Full experimental information is available from OCA.
