2hnx: Difference between revisions
New page: left|200px<br /> <applet load="2hnx" size="450" color="white" frame="true" align="right" spinBox="true" caption="2hnx, resolution 1.50Å" /> '''Crystal Structure o... |
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[[Image:2hnx.gif|left|200px]]<br /> | [[Image:2hnx.gif|left|200px]]<br /><applet load="2hnx" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="2hnx" size=" | |||
caption="2hnx, resolution 1.50Å" /> | caption="2hnx, resolution 1.50Å" /> | ||
'''Crystal Structure of aP2'''<br /> | '''Crystal Structure of aP2'''<br /> | ||
==Overview== | ==Overview== | ||
Human adipocyte lipid-binding protein (aP2) belongs to a family of | Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity. | ||
==About this Structure== | ==About this Structure== | ||
2HNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with PO4, PLM and ACY as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 2HNX is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=PLM:'>PLM</scene> and <scene name='pdbligand=ACY:'>ACY</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HNX OCA]. | ||
==Reference== | ==Reference== | ||
Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta | Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17077479 17077479] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: Karam, G.]] | [[Category: Karam, G.]] | ||
[[Category: Marr, E.]] | [[Category: Marr, E.]] | ||
[[Category: Phillips, T | [[Category: Phillips, T Brown.]] | ||
[[Category: Qiu, X.]] | [[Category: Qiu, X.]] | ||
[[Category: Tardie, M.]] | [[Category: Tardie, M.]] | ||
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[[Category: fatty acid binding protein]] | [[Category: fatty acid binding protein]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:43:45 2008'' | ||
Revision as of 15:43, 21 February 2008
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Crystal Structure of aP2
Overview
Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity.
About this Structure
2HNX is a Single protein structure of sequence from Homo sapiens with PO4, PLM and ACY as ligands. Full crystallographic information is available from OCA.
Reference
Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:17077479
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