4gr3: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4gr3| PDB=4gr3 | SCENE= }} | {{STRUCTURE_4gr3| PDB=4gr3 | SCENE= }} | ||
===Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A=== | ===Crystal structure of the catalytic domain of Human MMP12 in complex with selective phosphinic inhibitor RXP470A=== | ||
{{ABSTRACT_PUBMED_23343195}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | |||
==About this Structure== | ==About this Structure== | ||
[[4gr3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR3 OCA]. | [[4gr3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GR3 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023343195</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Macrophage elastase]] | [[Category: Macrophage elastase]] | ||
