4isu: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.===

The ~~entry 4isu~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>

~~Authors~~: ~~Juknaite, L~~.~~, Frydenvang, K~~.~~, Kastrup~~. J.S.

==About this Structure==

[[4isu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISU OCA].

~~Description~~: ~~Crystal structure of the GluA2~~ ligand-binding domain ~~(S1S2J) in complex with the antagonist (2R)~~-~~IKM~~-~~159 at 2.3A resolution.~~

==Reference==

[[Category: Rattus norvegicus]]

[[Category: Frydenvang, K.]]

[[Category: Juknaite, L.]]

[[Category: Kastrup, J S.]]

[[Category: Ampa receptor ligand-binding domain]]

[[Category: Antagonist]]

[[Category: Glur2-s1s2j]]

[[Category: Membrane protein]]

[[Category: Membrane protein-antagonist complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4isu|  PDB=4isu  |  SCENE=  }}
+===Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.===
+{{ABSTRACT_PUBMED_23432124}}
-The entry 4isu is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
-Authors: Juknaite, L., Frydenvang, K., Kastrup. J.S.
+==About this Structure==
+[[4isu]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISU OCA].
-Description: Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the antagonist (2R)-IKM-159 at 2.3A resolution.
+==Reference==
+<ref group="xtra">PMID:023432124</ref><references group="xtra"/><references/>
+[[Category: Rattus norvegicus]]
+[[Category: Frydenvang, K.]]
+[[Category: Juknaite, L.]]
+[[Category: Kastrup, J S.]]
+[[Category: Ampa receptor ligand-binding domain]]
+[[Category: Antagonist]]
+[[Category: Glur2-s1s2j]]
+[[Category: Membrane protein]]
+[[Category: Membrane protein-antagonist complex]]