3b2e: Difference between revisions
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{{STRUCTURE_3b2e| PDB=3b2e | SCENE= }} | {{STRUCTURE_3b2e| PDB=3b2e | SCENE= }} | ||
===Crystal structure of S. cerevisiae Get3 in the open conformation in complex with Get1 cytosolic domain=== | ===Crystal structure of S. cerevisiae Get3 in the open conformation in complex with Get1 cytosolic domain=== | ||
{{ABSTRACT_PUBMED_22684149}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GET1_YEAST GET1_YEAST]] Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in mitochondrial distribution and morphology.<ref>PMID:11907266</ref> <ref>PMID:16269340</ref> <ref>PMID:18724936</ref> <ref>PMID:21835666</ref> <ref>PMID:21719644</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3b2e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B2E OCA]. | [[3b2e]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae] and [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B2E OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022684149</ref><references group="xtra"/> | <ref group="xtra">PMID:022684149</ref><references group="xtra"/><references/> | ||
[[Category: Arsenite-transporting ATPase]] | [[Category: Arsenite-transporting ATPase]] | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Saccharomyces cerevisiae s288c]] | |||
[[Category: Fukai, S.]] | [[Category: Fukai, S.]] | ||
[[Category: Kubota, K.]] | [[Category: Kubota, K.]] | ||
