Caspase: Difference between revisions

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{{STRUCTURE_1pyo| PDB=1pyo | SIZE=400| SCENE= |right| CAPTION=CASP-2 subunit P18 (grey, pink) and subunit P12 (green, yellow) complex with polypeptide inhibitor (magenta, cyan), aspartic aldehyde and acetyl group, [[1pyo]] }}

'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-7 is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.

'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. '''CASP-1''' (or I'''nterleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. '''CASP-3''' interacts with CASP-8 and CASP-9 during cell apoptosis. '''CASP-7''' is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits. CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. '''Metacaspase''' (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.

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   {{STRUCTURE_1pyo| PDB=1pyo  | SIZE=400| SCENE= |right|   CAPTION=CASP-2 subunit P18 (grey, pink) and subunit P12 (green, yellow) complex with polypeptide inhibitor (magenta, cyan), aspartic aldehyde and acetyl group, [[1pyo]] }}
-'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation.  Twelve CASP have been identified in human.  CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active.  The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.  CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein.  CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis.  CASP-7 is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits.  CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''.  Metacaspase (MCASP) are arginine/lysine specific CASP.  MCASP are found in plants and fungi.
+'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation.  Twelve CASP have been identified in human.  CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active.  The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP.  '''CASP-1''' (or I'''nterleukin-1 beta converting enzyme, ICE''') cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein.  '''CASP-3''' interacts with CASP-8 and CASP-9 during cell apoptosis.  '''CASP-7''' is a heterodimer consisting of P20 (human residues 1-198) and P11 (human residues 199-303) subunits.  CASP-7 catalytic domain consists of residues 57-303. is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''.  '''Metacaspase''' (MCASP) are arginine/lysine specific CASP.  MCASP are found in plants and fungi.
 For some details see:<br />