3pwe: Difference between revisions
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{{STRUCTURE_3pwe| PDB=3pwe | SCENE= }} | {{STRUCTURE_3pwe| PDB=3pwe | SCENE= }} | ||
===Crystal structure of the E. coli beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution=== | ===Crystal structure of the E. coli beta clamp mutant R103C, I305C, C260S, C333S at 2.2A resolution=== | ||
{{ABSTRACT_PUBMED_21971175}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DPO3B_ECOLI DPO3B_ECOLI]] DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP-independent) along duplex DNA. | |||
==About this Structure== | ==About this Structure== | ||
[[3pwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | [[3pwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PWE OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021971175</ref><references group="xtra"/> | <ref group="xtra">PMID:021971175</ref><references group="xtra"/><references/> | ||
[[Category: DNA-directed DNA polymerase]] | [[Category: DNA-directed DNA polymerase]] | ||
[[Category: Escherichia coli]] | [[Category: Escherichia coli k-12]] | ||
[[Category: Bloom, L B.]] | [[Category: Bloom, L B.]] | ||
[[Category: Marzahn, M R.]] | [[Category: Marzahn, M R.]] | ||
