2qsh: Difference between revisions
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{{STRUCTURE_2qsh| PDB=2qsh | SCENE= }} | {{STRUCTURE_2qsh| PDB=2qsh | SCENE= }} | ||
===Crystal structure of Rad4-Rad23 bound to a mismatch DNA=== | ===Crystal structure of Rad4-Rad23 bound to a mismatch DNA=== | ||
{{ABSTRACT_PUBMED_17882165}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/RAD23_YEAST RAD23_YEAST]] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. [[http://www.uniprot.org/uniprot/RAD4_YEAST RAD4_YEAST]] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:017882165</ref><references group="xtra"/> | <ref group="xtra">PMID:017882165</ref><references group="xtra"/><references/> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Saccharomyces cerevisiae]] | ||
[[Category: Min, J H.]] | [[Category: Min, J H.]] | ||
Revision as of 07:29, 30 June 2013
Crystal structure of Rad4-Rad23 bound to a mismatch DNA
Template:ABSTRACT PUBMED 17882165
Function
[RAD23_YEAST] Plays a central role both in proteasomal degradation of misfolded proteins and DNA repair. Central component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. Involved in DNA excision repair. May play a part in DNA damage recognition and/or in altering chromatin structure to allow access by damage-processing enzymes. [RAD4_YEAST] Involved in nucleotide excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents.
About this Structure
2qsh is a 4 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
- Min JH, Pavletich NP. Recognition of DNA damage by the Rad4 nucleotide excision repair protein. Nature. 2007 Oct 4;449(7162):570-5. Epub 2007 Sep 19. PMID:17882165 doi:10.1038/nature06155
