2bc8: Difference between revisions
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{{STRUCTURE_2bc8| PDB=2bc8 | SCENE= }} | {{STRUCTURE_2bc8| PDB=2bc8 | SCENE= }} | ||
===[Sec2,3,8,12]-ImI=== | ===[Sec2,3,8,12]-ImI=== | ||
{{ABSTRACT_PUBMED_16500898}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CA1_CONIM CA1_CONIM]] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.<ref>PMID:8206995</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:016500898</ref><references group="xtra"/> | <ref group="xtra">PMID:016500898</ref><references group="xtra"/><references/> | ||
[[Category: Armishaw, C J.]] | [[Category: Armishaw, C J.]] | ||
[[Category: Conotoxin]] | [[Category: Conotoxin]] | ||
Revision as of 07:43, 30 June 2013
[Sec2,3,8,12]-ImI
Template:ABSTRACT PUBMED 16500898
Function
[CA1_CONIM] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks mammalian neuronal nAChRs (alpha-3/beta-2 > alpha-7 > alpha-3/beta-4). Has no effect on nAChRs composed of alpha-2/beta-2, alpha-3/beta-2, alpha-4/beta-2, alpha-2/beta-4, alpha-3/beta-4, or alpha-4/beta-4 subunits. Acts voltage-independently. Is highly active against the neuromuscular receptor in frog.[1]
About this Structure
2bc8 is a 1 chain structure. Full experimental information is available from OCA.
Reference
- Armishaw CJ, Daly NL, Nevin ST, Adams DJ, Craik DJ, Alewood PF. Alpha-selenoconotoxins, a new class of potent alpha7 neuronal nicotinic receptor antagonists. J Biol Chem. 2006 May 19;281(20):14136-43. Epub 2006 Feb 24. PMID:16500898 doi:M512419200
