3w9y: Difference between revisions
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{{STRUCTURE_3w9y| PDB=3w9y | SCENE= }} | |||
===Crystal structure of the human DLG1 guanylate kinase domain=== | |||
{{ABSTRACT_PUBMED_23624197}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DLG1_HUMAN DLG1_HUMAN]] Essential multidomain scaffolding protein required for normal development (By similarity). Recruits channels, receptors and signaling molecules to discrete plasma membrane domains in polarized cells. May play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation. Regulates the excitability of cardiac myocytes by modulating the functional expression of Kv4 channels. Functional regulator of Kv1.5 channel.<ref>PMID:10656683</ref> <ref>PMID:12445884</ref> <ref>PMID:14699157</ref> <ref>PMID:15263016</ref> <ref>PMID:19213956</ref> <ref>PMID:20605917</ref> | |||
==About this Structure== | |||
[[3w9y]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3W9Y OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023624197</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Akiyama, T.]] | |||
[[Category: Arakawa, A.]] | |||
[[Category: Handa, N.]] | |||
[[Category: Mori, S.]] | |||
[[Category: Shirouzu, M.]] | |||
[[Category: Tezuka, Y.]] | |||
[[Category: Yokoyama, S.]] | |||
[[Category: Cell membrane]] | |||
[[Category: Guanylate kinase]] | |||
[[Category: Molecular scaffold]] | |||
[[Category: Peptide binding]] | |||
[[Category: Peptide binding protein]] | |||