4awb: Difference between revisions
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{{STRUCTURE_4awb| PDB=4awb | SCENE= }} | |||
===Crystal structure of active legumain in complex with AAN-CMK=== | |||
{{ABSTRACT_PUBMED_23776206}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LGMN_HUMAN LGMN_HUMAN]] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system. | |||
==About this Structure== | |||
[[4awb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AWB OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023776206</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Legumain]] | |||
[[Category: Brandstetter, H.]] | |||
[[Category: Dall, E.]] | |||
[[Category: Aep]] | |||
[[Category: Antigen processing]] | |||
[[Category: Cancer]] | |||
[[Category: Cysteine protease]] | |||
[[Category: Hydrolase]] | |||
[[Category: Hydrolase-inhibitor complex]] | |||
[[Category: Lysosomal]] | |||
[[Category: Mhcii]] | |||
[[Category: Substrate specificity]] | |||
Revision as of 09:51, 30 June 2013
Crystal structure of active legumain in complex with AAN-CMK
Template:ABSTRACT PUBMED 23776206
Function
[LGMN_HUMAN] Has a strict specificity for hydrolysis of asparaginyl bonds. Can also cleave aspartyl bonds slowly, especially under acidic conditions. May be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system.
About this Structure
4awb is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Dall E, Brandstetter H. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc Natl Acad Sci U S A. 2013 Jun 17. PMID:23776206 doi:10.1073/pnas.1300686110
