4idj: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4idj| PDB=4idj | SCENE= }} | |||
===S.Aureus a-hemolysin monomer in complex with Fab=== | |||
{{ABSTRACT_PUBMED_23416200}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU]] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity. | |||
==About this Structure== | |||
[[4idj]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IDJ OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023416200</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Staphylococcus aureus]] | |||
[[Category: Strop, P.]] | |||
[[Category: Cytolytic protein]] | |||
[[Category: Fab]] | |||
[[Category: Hemolysin complex with fab]] | |||
[[Category: Immune system]] | |||
[[Category: Secreted]] | |||
Revision as of 09:51, 30 June 2013
S.Aureus a-hemolysin monomer in complex with Fab
Template:ABSTRACT PUBMED 23416200
Function
[HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
About this Structure
4idj is a 3 chain structure with sequence from Homo sapiens and Staphylococcus aureus. Full crystallographic information is available from OCA.
Reference
- Foletti D, Strop P, Shaughnessy L, Hasa-Moreno A, Casas MG, Russell M, Bee C, Wu S, Pham A, Zeng Z, Pons J, Rajpal A, Shelton D. Mechanism of action and in vivo efficacy of a human-derived antibody against Staphylococcus aureus alpha-hemolysin. J Mol Biol. 2013 May 27;425(10):1641-54. doi: 10.1016/j.jmb.2013.02.008. Epub, 2013 Feb 13. PMID:23416200 doi:10.1016/j.jmb.2013.02.008
