4jbk: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4jbk|  PDB=4jbk  |  SCENE=  }}
===Molecular basis for abrogation of activation of pro-inflammatory cytokines===


The entry 4jbk is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref>  


Authors: Ru, H., Ni, X.-M., Crowley, C., Zhao, L.-X., Ding, W., Hung, L.-W., Shaw, N., Cheng, G.-H., Liu, Z.-J.
==About this Structure==
[[4jbk]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JBK OCA].  


Description: Molecular basis for abrogation of activation of pro-inflammatory cytokines
==Reference==
<ref group="xtra">PMID:023567559</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Cheng, G.]]
[[Category: Crowley, C.]]
[[Category: Ding, W.]]
[[Category: Hung, L W.]]
[[Category: Liu, Z J.]]
[[Category: Ni, X.]]
[[Category: Ru, H.]]
[[Category: Shaw, N.]]
[[Category: Zhao, L.]]
[[Category: Dna]]
[[Category: Dna binding protein-dna complex]]
[[Category: Ob fold]]
Retrieved from "https://proteopedia.org/4jbk"