Integrin: Difference between revisions
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<StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''> | <StructureSection load='1zoo' size='400' side='right' caption='Structure of human integrein CD11a I domain dimer complex with Mg+2 (light green) and Cl- (dark green) ions (PDB entry [[1zoo]])' scene=''> | ||
'''Integrins''' (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α | '''Integrins''' (IG) are receptors which mediate the attachment between cells or to extracellular matrix. They are involved in cellular signaling and cell cycle. IGs contain α and β chain. IG subunits span the cell membrane. Both subunits bind divalent cations some of which bind the ligands which interact with IG. Some IGs contain an insertion domain named I domain. | ||
==3D structures of integrin== | ==3D structures of integrin== | ||
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[[1n3y]] - hIG I domain (mutant) | [[1n3y]] - hIG I domain (mutant) | ||
===IG α-1=== | ===IG α-1 (CD49a)=== | ||
[[1ck4]] - rIG I domain – rat<br /> | [[1ck4]] - rIG I domain – rat<br /> | ||
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[[1mhp]] - rIG I domain (mutant) + antibody + Mn<br /> | [[1mhp]] - rIG I domain (mutant) + antibody + Mn<br /> | ||
===IG α-2=== | ===IG α-2 (CD49b)=== | ||
[[1dzi]] - hIG I domain + collagen peptide<br /> | [[1dzi]] - hIG I domain + collagen peptide<br /> | ||
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[[2luv]] – hIG cytoplasmic domain – NMR<BR /> | [[2luv]] – hIG cytoplasmic domain – NMR<BR /> | ||
===IG α-1 β-1=== | ===IG α-1 β-1 (CD49a-CD49b)=== | ||
[[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br /> | [[1qc5]], [[1qcy]] - hIG I domain (mutant) + Mg<br /> | ||
[[1pt6]] - hIG I domain + Mg<br /> | [[1pt6]] - hIG I domain + Mg<br /> | ||
===IG α-2 β=== | ===IG α-2 (CD49b) β=== | ||
[[1aox]] - hIG I domain (mutant) + Mg<br /> | [[1aox]] - hIG I domain (mutant) + Mg<br /> | ||
[[1s4w]] - hIG cytoplasmic domain]] - NMR<BR /> | [[1s4w]] - hIG cytoplasmic domain]] - NMR<BR /> | ||
===IG α-2b β-3=== | ===IG α-2b β-3 (CD61)=== | ||
[[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR /> | [[1kup]], [[1kuz]] – hIG proximal domain – NMR<BR /> | ||
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[[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br /> | [[2vdo]], [[2vdp]], [[2vdq]], [[2vdr]] – hIG headpiece + antibody + fibrinogen peptide + Mg<br /> | ||
===IG α-4 β-7=== | ===IG α-4 (CD49d) β-7=== | ||
[[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br /> | [[3v4p]] - hIG headpiece (mutant) + antibody + Mg<br /> | ||
[[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br /> | [[3v4v]] - hIG headpiece (mutant) + antibody + inhibitor + Mg<br /> | ||
===IG α-5 β-1=== | ===IG α-5 (CD49e) β-1 (CD29)=== | ||
[[3vi3]] - hIG headpiece + antibody + Mg<br /> | [[3vi3]] - hIG headpiece + antibody + Mg<br /> | ||
[[3vi4]] - hIG headpiece + antibody + peptide + Mg<br /> | [[3vi4]] - hIG headpiece + antibody + peptide + Mg<br /> | ||
===IG α-5 β-3=== | ===IG α-5 (CD49e) β-3 (CD61)=== | ||
[[3ije]] – hIG + Ca<br /> | [[3ije]] – hIG + Ca<br /> | ||
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[[1l5g]] - hIG I domain + tripeptide + Mn<br /> | [[1l5g]] - hIG I domain + tripeptide + Mn<br /> | ||
===IG α-X β-2=== | ===IG α-X β-2 (CD18)=== | ||
[[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br /> | [[3k6s]], [[3k71]], [[3k72]] – hIG + Mg<br /> | ||
===IG β-2=== | ===IG β-2 (CD18)=== | ||
[[2p26]], [[2p28]] – hIG phe2 + phe3 domains | [[2p26]], [[2p28]] – hIG phe2 + phe3 domains | ||
===IG β-3=== | ===IG β-3 (CD61)=== | ||
[[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR /> | [[1s4x]], [[2kv9]], [[2ljd]], [[2lje]], [[2ljf]] – hIG cytoplasmic domain – NMR<BR /> | ||
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[[2l91]] - hIG transmembrane domain (mutant) – NMR<BR /> | [[2l91]] - hIG transmembrane domain (mutant) – NMR<BR /> | ||
===IG β-4=== | ===IG β-4 (CD104)=== | ||
[[2f7q]], [[3f7r]] - hIG fibronectin type III domain<br /> | [[2f7q]], [[3f7r]] - hIG fibronectin type III domain<br /> | ||
