3s9b: Difference between revisions

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[[Image:3s9b.jpg|left|200px]]
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{{STRUCTURE_3s9b|  PDB=3s9b  |  SCENE=  }}  
{{STRUCTURE_3s9b|  PDB=3s9b  |  SCENE=  }}  
===Russell's viper venom serine proteinase, RVV-V (open-form)===
===Russell's viper venom serine proteinase, RVV-V (open-form)===
{{ABSTRACT_PUBMED_21871889}}


 
==Function==
<!--
[[http://www.uniprot.org/uniprot/VSPG_DABSI VSPG_DABSI]] Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma.<ref>PMID:3053712</ref>
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{{ABSTRACT_PUBMED_21871889}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:021871889</ref><ref group="xtra">PMID:020054136</ref><references group="xtra"/>
<ref group="xtra">PMID:021871889</ref><references group="xtra"/><references/>
[[Category: Daboia russellii siamensis]]
[[Category: Daboia russellii siamensis]]
[[Category: Snake venom factor V activator]]
[[Category: Snake venom factor V activator]]

Revision as of 07:08, 3 July 2013

Template:STRUCTURE 3s9b

Russell's viper venom serine proteinase, RVV-V (open-form)

Template:ABSTRACT PUBMED 21871889

Function

[VSPG_DABSI] Venom serine protease that selectively activates factor V (F5) in a calcium-independent manner. It cleaves the Arg(1545)-Ser(1546) linkage in the human factor V molecule. Induces the coagulation of mammalian plasma.[1]

About this Structure

3s9b is a 1 chain structure with sequence from Daboia russellii siamensis. Full crystallographic information is available from OCA.

Reference

  1. Nakayama D, Ben Ammar Y, Miyata T, Takeda S. Structural basis of coagulation factor V recognition for cleavage by RVV-V. FEBS Lett. 2011 Aug 23. PMID:21871889 doi:10.1016/j.febslet.2011.08.022
  1. ↑ Tokunaga F, Nagasawa K, Tamura S, Miyata T, Iwanaga S, Kisiel W. The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences. J Biol Chem. 1988 Nov 25;263(33):17471-81. PMID:3053712

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