4da1: Difference between revisions

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[[Image:4da1.jpg|left|200px]]
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{{STRUCTURE_4da1|  PDB=4da1  |  SCENE=  }}  
{{STRUCTURE_4da1|  PDB=4da1  |  SCENE=  }}  
===Crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with Mg (II) ions at the active site===
{{ABSTRACT_PUBMED_22291014}}


===Crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with Mg (II) ions at the active site===
==Disease==
[[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Intermediate maple syrup urine disease. 


==Function==
[[http://www.uniprot.org/uniprot/PPM1K_HUMAN PPM1K_HUMAN]] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.<ref>PMID:17374715</ref> 


==About this Structure==
==About this Structure==
[[4da1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DA1 OCA].  
[[4da1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DA1 OCA].  
==Reference==
<ref group="xtra">PMID:022291014</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Phosphoprotein phosphatase]]
[[Category: Phosphoprotein phosphatase]]

Revision as of 09:44, 3 July 2013

Template:STRUCTURE 4da1

Crystal structure of branched-chain alpha-ketoacid dehydrogenase phosphatase with Mg (II) ions at the active site

Template:ABSTRACT PUBMED 22291014

Disease

[PPM1K_HUMAN] Intermediate maple syrup urine disease.

Function

[PPM1K_HUMAN] Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development.[1]

About this Structure

4da1 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Wynn RM, Li J, Brautigam CA, Chuang JL, Chuang DT. Structural and biochemical characterization of human mitochondrial branched-chain alpha-ketoacid dehydrogenase phosphatase. J Biol Chem. 2012 Mar 16;287(12):9178-92. Epub 2012 Jan 30. PMID:22291014 doi:10.1074/jbc.M111.314963
  1. ↑ Lu G, Ren S, Korge P, Choi J, Dong Y, Weiss J, Koehler C, Chen JN, Wang Y. A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. Genes Dev. 2007 Apr 1;21(7):784-96. Epub 2007 Mar 20. PMID:17374715 doi:https://dx.doi.org/10.1101/gad.1499107

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