4k60: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4k60]] is a 1 chain structure | [[4k60]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K60 OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023659209</ref><references group="xtra"/><references/> | ||
[[Category: Chymase]] | [[Category: Chymase]] | ||
[[Category: Collins, B K.]] | [[Category: Collins, B K.]] | ||
[[Category: Padyana, A K.]] | [[Category: Padyana, A K.]] | ||
Revision as of 10:18, 3 July 2013
Crystal Structure of Human Chymase in Complex with Fragment 6-bromo-1,3-dihydro-2H-indol-2-one
Template:ABSTRACT PUBMED 23659209
Function
[CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
About this Structure
4k60 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Taylor SJ, Padyana AK, Abeywardane A, Liang S, Hao MH, De Lombaert S, Proudfoot JR, Farmer BS, Li X, Collins B, Albaugh DR, Martin L, Hill-Drzewi M, Pullen SS, Takahashi H. Discovery of Potent, Selective Chymase Inhibitors via Fragment Linking Strategies. J Med Chem. 2013 May 9. PMID:23659209 doi:10.1021/jm400138z
