4ef5: Difference between revisions

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Bots, Bureaucrats, journal, Administrators
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[[Image:4ef5.png|left|200px]]
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The line below this paragraph, containing "STRUCTURE_4ef5", creates the "Structure Box" on the page.
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{{STRUCTURE_4ef5|  PDB=4ef5  |  SCENE=  }}  
{{STRUCTURE_4ef5|  PDB=4ef5  |  SCENE=  }}  
===Crystal structure of STING CTD===
===Crystal structure of STING CTD===
{{ABSTRACT_PUBMED_22579474}}


 
==Function==
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[[http://www.uniprot.org/uniprot/STING_HUMAN STING_HUMAN]] Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.<ref>PMID:18818105</ref> <ref>PMID:18724357</ref> <ref>PMID:19776740</ref> <ref>PMID:19433799</ref> <ref>PMID:21074459</ref> <ref>PMID:21947006</ref> <ref>PMID:23258412</ref> 
The line below this paragraph, {{ABSTRACT_PUBMED_22579474}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_22579474}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:022579474</ref><references group="xtra"/>
<ref group="xtra">PMID:022579474</ref><references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Jiang, Y.]]
[[Category: Jiang, Y.]]
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