3syv: Difference between revisions

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[[Image:3syv.jpg|left|200px]]
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{{STRUCTURE_3syv|  PDB=3syv  |  SCENE=  }}  
{{STRUCTURE_3syv|  PDB=3syv  |  SCENE=  }}  
===Crystal structure of mPACSIN 3 F-BAR domain mutant===
===Crystal structure of mPACSIN 3 F-BAR domain mutant===
{{ABSTRACT_PUBMED_22573331}}


==Function==
[[http://www.uniprot.org/uniprot/PACN3_MOUSE PACN3_MOUSE]] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.


==About this Structure==
==About this Structure==
[[3syv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYV OCA].  
[[3syv]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SYV OCA].  
==Reference==
<ref group="xtra">PMID:022573331</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Bai, X.]]
[[Category: Bai, X.]]

Revision as of 12:36, 3 July 2013

Template:STRUCTURE 3syv

Crystal structure of mPACSIN 3 F-BAR domain mutant

Template:ABSTRACT PUBMED 22573331

Function

[PACN3_MOUSE] Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity.

About this Structure

3syv is a 8 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

  1. Bai X, Meng G, Luo M, Zheng X. The rigidity of the wedge loop in PACSIN 3 is a key factor in dictating the diameters of tubules. J Biol Chem. 2012 May 9. PMID:22573331 doi:10.1074/jbc.M112.358960

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