2i6e: Difference between revisions

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==Overview==

~~ABSTRACT:~~ BACKGROUND: Pfam is a comprehensive collection of protein, domains and families, with a range of well-established information, including genome annotation. Pfam has two large series of functionally, uncharacterized families, known as Domains of Unknown Function (DUFs) and, Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of, two proteins from Deinococcus radiodurans and Streptomyces coelicolor, belonging to Pfam protein family DUF178 (ID: PF02621) have been determined, using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on, the structure, we have identified the putative function for this family of, protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably, similar to Pfam family DUF191 suggesting that the sequence-based, classification alone may not be sufficient to classify proteins into Pfam, families.

BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.

==About this Structure==

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==Reference==

X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7~~(1)~~:62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]

X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]

[[Category: Deinococcus radiodurans]]

[[Category: Single protein]]

[[Category: Burley, S.K.]]

[[Category: Burley, S K.]]

[[Category: Kumaran, D.]]

[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]

[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]

[[Category: Swaminathan, S.]]

[[Category: Tyagi, R.]]

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[[Category: unknown function]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-ABSTRACT: BACKGROUND: Pfam is a comprehensive collection of protein, domains and families, with a range of well-established information, including genome annotation. Pfam has two large series of functionally, uncharacterized families, known as Domains of Unknown Function (DUFs) and, Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of, two proteins from Deinococcus radiodurans and Streptomyces coelicolor, belonging to Pfam protein family DUF178 (ID: PF02621) have been determined, using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on, the structure, we have identified the putative function for this family of, protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably, similar to Pfam family DUF191 suggesting that the sequence-based, classification alone may not be sufficient to classify proteins into Pfam, families.
+BACKGROUND: Pfam is a comprehensive collection of protein domains and families, with a range of well-established information including genome annotation. Pfam has two large series of functionally uncharacterized families, known as Domains of Unknown Function (DUFs) and Uncharacterized Protein Families (UPFs). RESULTS: Crystal structures of two proteins from Deinococcus radiodurans and Streptomyces coelicolor belonging to Pfam protein family DUF178 (ID: PF02621) have been determined using Selenium-Single-wavelength Anomalous Dispersion (Se-SAD). Based on the structure, we have identified the putative function for this family of protein. CONCLUSION: Unexpectedly, we found that DUF178 Pfam is remarkably similar to Pfam family DUF191 suggesting that the sequence-based classification alone may not be sufficient to classify proteins into Pfam families.
 ==About this Structure==
@@ Line 10: / Line 10: @@
 ==Reference==
-X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7(1):62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]
+X-ray structures of two proteins belonging to Pfam DUF178 revealed unexpected structural similarity to the DUF191 Pfam family., Tyagi R, Burley SK, Swaminathan S, BMC Struct Biol. 2007 Oct 1;7:62. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17908300 17908300]
 [[Category: Deinococcus radiodurans]]
 [[Category: Single protein]]
-[[Category: Burley, S.K.]]
+[[Category: Burley, S K.]]
 [[Category: Kumaran, D.]]
-[[Category: NYSGXRC, New.York.Structural.GenomiX.Research.Consortium.]]
+[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
 [[Category: Swaminathan, S.]]
 [[Category: Tyagi, R.]]
@@ Line 29: / Line 29: @@
 [[Category: unknown function]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 12:48:56 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:49:35 2008''