4hfd: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[4hfd]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFD OCA]. | [[4hfd]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Gloeobacter_violaceus_pcc_7421 Gloeobacter violaceus pcc 7421]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HFD OCA]. | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:023591864</ref><references group="xtra"/><references/> | <ref group="xtra">PMID:023591864</ref><references group="xtra"/><references/> | ||
[[Category: Gloeobacter violaceus pcc 7421]] | |||
[[Category: Corringer, P J.]] | [[Category: Corringer, P J.]] | ||
[[Category: Delarue, M.]] | [[Category: Delarue, M.]] | ||
Revision as of 14:08, 3 July 2013
The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant complexed to bromoform
Template:ABSTRACT PUBMED 23591864
Function
[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]
About this Structure
4hfd is a 5 chain structure with sequence from Gloeobacter violaceus pcc 7421. Full crystallographic information is available from OCA.
Reference
- Sauguet L, Howard RJ, Malherbe L, Lee US, Corringer PJ, Harris RA, Delarue M. Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel. Nat Commun. 2013;4:1697. doi: 10.1038/ncomms2682. PMID:23591864 doi:10.1038/ncomms2682
- ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371
