4i91: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4i91| PDB=4i91 | SCENE= }} | |||
===Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CP2B6_HUMAN CP2B6_HUMAN]] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.<ref>PMID:11695850</ref> | |||
==About this Structure== | |||
[[4i91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I91 OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Halpert, J R.]] | |||
[[Category: Shah, M B.]] | |||
[[Category: Stout, C D.]] | |||
[[Category: Cyp2b6]] | |||
[[Category: Cytochrome p450 2b6]] | |||
[[Category: Endoplasmic reticulum]] | |||
[[Category: Heme]] | |||
[[Category: Iron]] | |||
[[Category: Membrane]] | |||
[[Category: Membrane protein]] | |||
[[Category: Metal binding]] | |||
[[Category: Microsome]] | |||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
[[Category: P450]] | |||
Revision as of 14:16, 3 July 2013
Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.
Function
[CP2B6_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.[1]
About this Structure
4i91 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Miyazawa M, Shindo M, Shimada T. Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. Xenobiotica. 2001 Oct;31(10):713-23. PMID:11695850 doi:10.1080/00498250110065595
