4j8c: Difference between revisions
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{{STRUCTURE_4j8c| PDB=4j8c | SCENE= }} | |||
===Crystal structure of the dimerization domain of Hsc70-interacting protein=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/F10A1_RAT F10A1_RAT]] One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins. | |||
==About this Structure== | |||
[[4j8c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8C OCA]. | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Bracher, A.]] | |||
[[Category: Li, Z.]] | |||
[[Category: Alpha helical dimer]] | |||
[[Category: Chaperone]] | |||
[[Category: Co-chaperone]] | |||
[[Category: Cytosol]] | |||
Revision as of 14:16, 3 July 2013
Crystal structure of the dimerization domain of Hsc70-interacting protein
Function
[F10A1_RAT] One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
About this Structure
4j8c is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
