4kbb: Difference between revisions

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~~'''Unreleased structure'''~~

===Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a===

~~The entry 4kbb~~ is ~~ON HOLD until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. [[http://www.uniprot.org/uniprot/SYT2_MOUSE SYT2_MOUSE]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.

~~Authors~~: Berntsson, R.P.A., Peng, L.~~, Dong, M.,~~ Stenmark, P.

==About this Structure==

[[4kbb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBB OCA].

~~Description~~: ~~Structure of Botulinum neurotoxin B~~ binding domain ~~in complex with both synaptotagmin II and GD1a~~

[[Category: Bontoxilysin]]

[[Category: Clostridium botulinum]]

[[Category: Mus musculus]]

[[Category: Berntsson, R P.A.]]

[[Category: Dong, M.]]

[[Category: Peng, L.]]

[[Category: Stenmark, P.]]

[[Category: Signaling protein-toxin complex]]

[[Category: Synaptotagmin and ganglioside]]

[[Category: Toxin binding domain]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4kbb|  PDB=4kbb  |  SCENE=  }}
+===Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a===
-The entry 4kbb is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/BXB_CLOBO BXB_CLOBO]] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that cleaves the '76-Gln-|-Phe-77' bond of synaptobrevin-2. [[http://www.uniprot.org/uniprot/SYT2_MOUSE SYT2_MOUSE]] May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.
-Authors: Berntsson, R.P.A., Peng, L., Dong, M., Stenmark, P.
+==About this Structure==
+[[4kbb]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KBB OCA].
-Description: Structure of Botulinum neurotoxin B binding domain in complex with both synaptotagmin II and GD1a
+[[Category: Bontoxilysin]]
+[[Category: Clostridium botulinum]]
+[[Category: Mus musculus]]
+[[Category: Berntsson, R P.A.]]
+[[Category: Dong, M.]]
+[[Category: Peng, L.]]
+[[Category: Stenmark, P.]]
+[[Category: Signaling protein-toxin complex]]
+[[Category: Synaptotagmin and ganglioside]]
+[[Category: Toxin binding domain]]