4l1m: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of the first RCC1-like domain of HERC2===

~~The entry 4l1m is ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN]] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>

~~Authors~~: ~~Tempel, W~~.~~, Khan, M~~.B.~~, Dong, A., Hu, J., Li, Y., Bountra, C., Arrowsmith, C.H~~.~~, Edwards, A~~.M.~~, Tong, Y~~.~~, Structural Genomics Consortium (SGC)~~

==About this Structure==

[[4l1m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1M OCA].

~~Description~~: ~~Structure of the first RCC1~~-~~like domain of HERC2~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Arrowsmith, C H.]]

[[Category: Bountra, C.]]

[[Category: Dong, A.]]

[[Category: Edwards, A M.]]

[[Category: Hu, J.]]

[[Category: Khan, M B.]]

[[Category: Li, Y.]]

[[Category: SGC, Structural Genomics Consortium.]]

[[Category: Tempel, W.]]

[[Category: Tong, Y.]]

[[Category: Beta-propeller]]

[[Category: Herc2]]

[[Category: Ligase]]

[[Category: Rcc1]]

[[Category: Rld]]

[[Category: Sgc]]

[[Category: Structural genomics consortium]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4l1m|  PDB=4l1m  |  SCENE=  }}
+===Structure of the first RCC1-like domain of HERC2===
-The entry 4l1m is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/HERC2_HUMAN HERC2_HUMAN]] E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity.<ref>PMID:20023648</ref> <ref>PMID:20304803</ref> <ref>PMID:22508508</ref>
-Authors: Tempel, W., Khan, M.B., Dong, A., Hu, J., Li, Y., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Tong, Y., Structural Genomics Consortium (SGC)
+==About this Structure==
+[[4l1m]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L1M OCA].
-Description: Structure of the first RCC1-like domain of HERC2
+==Reference==
+<references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Arrowsmith, C H.]]
+[[Category: Bountra, C.]]
+[[Category: Dong, A.]]
+[[Category: Edwards, A M.]]
+[[Category: Hu, J.]]
+[[Category: Khan, M B.]]
+[[Category: Li, Y.]]
+[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Tempel, W.]]
+[[Category: Tong, Y.]]
+[[Category: Beta-propeller]]
+[[Category: Herc2]]
+[[Category: Ligase]]
+[[Category: Rcc1]]
+[[Category: Rld]]
+[[Category: Sgc]]
+[[Category: Structural genomics consortium]]