4gur: Difference between revisions
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{{STRUCTURE_4gur| PDB=4gur | SCENE= }} | {{STRUCTURE_4gur| PDB=4gur | SCENE= }} | ||
===Crystal structure of LSD2-NPAC with H3 in space group P21=== | ===Crystal structure of LSD2-NPAC with H3 in space group P21=== | ||
{{ABSTRACT_PUBMED_23260659}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLYR1_HUMAN GLYR1_HUMAN]] May have oxidoreductase activity. Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling. Indirectly promotes phosphorylation of MAPK14 and activation of ATF2. The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6. Recruited on chromatin, recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3).<ref>PMID:16352664</ref> <ref>PMID:20850016</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4gur]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUR OCA]. | [[4gur]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GUR OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023260659</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Chen, F.]] | [[Category: Chen, F.]] | ||
