2ic6: Difference between revisions
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New page: left|200px<br /><applet load="2ic6" size="350" color="white" frame="true" align="right" spinBox="true" caption="2ic6, resolution 1.150Å" /> '''The Coiled-coil Dom... |
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==Overview== | ==Overview== | ||
Hantaviruses can cause hemorrhagic fever with a renal syndrome and | Hantaviruses can cause hemorrhagic fever with a renal syndrome and hantavirus pulmonary syndrome when transmitted to humans. The nucleocapsid protein of hantaviruses encapsidates viral genomic RNA and associates with transcription and replication complexes. Both the amino and carboxy termini of the nucleocapsid protein had been predicted to form trimers prior to the formation of the ribonucleoprotein. Crystal structures of amino-terminal fragments of the nucleocapsid protein showed the formation of intramolecular antiparallel coiled coils, but not intermolecular trimers. Thus, the amino-terminal part of the nucleocapsid protein is probably insufficient to initiate the trimerization of the full-length molecule. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Sin nombre virus]] | [[Category: Sin nombre virus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Boudko, S | [[Category: Boudko, S P.]] | ||
[[Category: Rossmann, M | [[Category: Rossmann, M G.]] | ||
[[Category: antiparallel coiled coil]] | [[Category: antiparallel coiled coil]] | ||
[[Category: bunyaviridae]] | [[Category: bunyaviridae]] | ||
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[[Category: ssrna negative-strand viruses]] | [[Category: ssrna negative-strand viruses]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:51:07 2008'' | ||
