4g87: Difference between revisions
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{{STRUCTURE_4g87| PDB=4g87 | SCENE= }} | {{STRUCTURE_4g87| PDB=4g87 | SCENE= }} | ||
===Crystal structure of GLMU from Mycobacterium tuberculosis snapshot 1=== | ===Crystal structure of GLMU from Mycobacterium tuberculosis snapshot 1=== | ||
{{ABSTRACT_PUBMED_23485416}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLMU_MYCTU GLMU_MYCTU]] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.<ref>PMID:19237750</ref> <ref>PMID:19121323</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4g87]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G87 OCA]. | [[4g87]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_h37rv Mycobacterium tuberculosis h37rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G87 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023485416</ref><references group="xtra"/><references/> | |||
[[Category: Mycobacterium tuberculosis h37rv]] | [[Category: Mycobacterium tuberculosis h37rv]] | ||
[[Category: Jagtap, P A.]] | [[Category: Jagtap, P A.]] | ||
Revision as of 14:25, 10 July 2013
Crystal structure of GLMU from Mycobacterium tuberculosis snapshot 1
Template:ABSTRACT PUBMED 23485416
Function
[GLMU_MYCTU] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.[1] [2]
About this Structure
4g87 is a 1 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA.
Reference
- Jagtap PK, Verma SK, Vithani N, Bais VS, Prakash B. Crystal structures identify an atypical two-metal-ion mechanism for uridyltransfer in GlmU: its significance to sugar nucleotidyl transferases. J Mol Biol. 2013 May 27;425(10):1745-59. doi: 10.1016/j.jmb.2013.02.019. Epub, 2013 Feb 26. PMID:23485416 doi:10.1016/j.jmb.2013.02.019
- ↑ Zhang Z, Bulloch EM, Bunker RD, Baker EN, Squire CJ. Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):275-83. Epub 2009, Feb 20. PMID:19237750 doi:10.1107/S0907444909001036
- ↑ Parikh A, Verma SK, Khan S, Prakash B, Nandicoori VK. PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity. J Mol Biol. 2009 Feb 20;386(2):451-64. Epub 2008 Dec 24. PMID:19121323 doi:10.1016/j.jmb.2008.12.031
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Mycobacterium tuberculosis h37rv
- Jagtap, P A.
- Prakash, B.
- Verma, S K.
- Acetyltransferase
- Acyltransferase
- Bifunctional
- Cell shape
- Cell wall biogenesis/degradation
- Left-handed-beta-helix
- Metal-binding
- Multifunctional enzyme
- Nucleotidyltransferase
- Peptidoglycan synthesis
- Pyrophosphorylase
- Rossmann-like fold
- Transferase
