2ica: Difference between revisions

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[[Image:2ica.gif|left|200px]]<br />

[[Image:2ica.gif|left|200px]]<br /><applet load="2ica" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2ica" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2ica, resolution 1.56Å" />

'''CD11a (LFA1) I-domain complexed with BMS-587101 aka 5-[(5S, 9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro [4.4]non-7-yl]methyl]-3-thiophenecarboxylicacid'''<br />

==Overview==

LFA-1 (leukocyte function-associated antigen-1), is a member of the, beta2-integrin family and is expressed on all leukocytes. This letter, describes the discovery and preliminary SAR of spirocyclic hydantoin based, LFA-1 antagonists that culminated in the identification of analog 8 as a, clinical candidate. We also report the first example of the efficacy of a, small molecule LFA-1 antagonist in combination with CTLA-4Ig in an animal, model of transplant rejection.

LFA-1 (leukocyte function-associated antigen-1), is a member of the beta2-integrin family and is expressed on all leukocytes. This letter describes the discovery and preliminary SAR of spirocyclic hydantoin based LFA-1 antagonists that culminated in the identification of analog 8 as a clinical candidate. We also report the first example of the efficacy of a small molecule LFA-1 antagonist in combination with CTLA-4Ig in an animal model of transplant rejection.

==About this Structure==

2ICA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 2IC as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2ICA OCA].

2ICA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=2IC:'>2IC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICA OCA].

==Reference==

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[[Category: protein/ligand complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 22~~:43:~~26 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:51:11 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2ica.gif|left|200px]]<br />
+[[Image:2ica.gif|left|200px]]<br /><applet load="2ica" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2ica" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2ica, resolution 1.56&Aring;" />
 '''CD11a (LFA1) I-domain complexed with BMS-587101 aka 5-[(5S, 9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro [4.4]non-7-yl]methyl]-3-thiophenecarboxylicacid'''<br />
 ==Overview==
-LFA-1 (leukocyte function-associated antigen-1), is a member of the, beta2-integrin family and is expressed on all leukocytes. This letter, describes the discovery and preliminary SAR of spirocyclic hydantoin based, LFA-1 antagonists that culminated in the identification of analog 8 as a, clinical candidate. We also report the first example of the efficacy of a, small molecule LFA-1 antagonist in combination with CTLA-4Ig in an animal, model of transplant rejection.
+LFA-1 (leukocyte function-associated antigen-1), is a member of the beta2-integrin family and is expressed on all leukocytes. This letter describes the discovery and preliminary SAR of spirocyclic hydantoin based LFA-1 antagonists that culminated in the identification of analog 8 as a clinical candidate. We also report the first example of the efficacy of a small molecule LFA-1 antagonist in combination with CTLA-4Ig in an animal model of transplant rejection.
 ==About this Structure==
-ICA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 2IC as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2ICA OCA].
+ICA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=2IC:'>2IC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ICA OCA].
 ==Reference==
@@ Line 20: / Line 19: @@
 [[Category: protein/ligand complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:43:26 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:51:11 2008''