3u10: Difference between revisions
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{{STRUCTURE_3u10| PDB=3u10 | SCENE= }} | {{STRUCTURE_3u10| PDB=3u10 | SCENE= }} | ||
===Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels=== | ===Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels=== | ||
{{ABSTRACT_PUBMED_22006928}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HCN2_HUMAN HCN2_HUMAN]] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
| Line 22: | Line 10: | ||
==Reference== | ==Reference== | ||
<ref group="xtra">PMID:022006928</ref><references group="xtra"/> | <ref group="xtra">PMID:022006928</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Arrigoni, C.]] | [[Category: Arrigoni, C.]] | ||
Revision as of 14:30, 10 July 2013
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Template:ABSTRACT PUBMED 22006928
Function
[HCN2_HUMAN] Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity).
About this Structure
3u10 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Lolicato M, Nardini M, Gazzarrini S, Moeller S, Bertinetti D, Herberg FW, Bolognesi M, Martin H, Fasolini M, Bertrand JA, Arrigoni C, Thiel G, Moroni A. Tetramerization dynamics of the C-terminal domain underlies isoform-specific cAMP-gating in Hyperpolarization-activated Cyclic Nucleotide gated channels. J Biol Chem. 2011 Oct 17. PMID:22006928 doi:10.1074/jbc.M111.297606
