4kp6: Difference between revisions
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{{STRUCTURE_4kp6| PDB=4kp6 | SCENE= }} | |||
===Crystal structure of human phosphodiesterase 4B (PDE4B) in complex with a [1,3,5]triazine derivative=== | |||
{{ABSTRACT_PUBMED_23806553}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref> | |||
==About this Structure== | |||
[[4kp6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KP6 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023806553</ref><references group="xtra"/><references/> | |||
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Egerland, U.]] | |||
[[Category: Gewald, R.]] | |||
[[Category: Grunwald, C.]] | |||
[[Category: Copd]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Neutrophilia]] | |||
[[Category: Pde4 inhibitor]] | |||
[[Category: Phosphodiesterase]] | |||
[[Category: Triazine]] | |||