3zl2: Difference between revisions
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{{STRUCTURE_3zl2| PDB=3zl2 | SCENE= }} | |||
===A thiazolyl-mannoside bound to FimH, orthorhombic space group=== | |||
{{ABSTRACT_PUBMED_23795713}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI]] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed. | |||
==About this Structure== | |||
[[3zl2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_j96 Escherichia coli j96]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZL2 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023795713</ref><references group="xtra"/><references/> | |||
[[Category: Escherichia coli j96]] | |||
[[Category: Bilyy, R O.]] | |||
[[Category: Bouckaert, J.]] | |||
[[Category: Brument, S.]] | |||
[[Category: Chalopin, T.]] | |||
[[Category: Darfeuille-Michaud, A.]] | |||
[[Category: Deniaud, D.]] | |||
[[Category: Dumych, T I.]] | |||
[[Category: Gouin, S G.]] | |||
[[Category: Guerardel, Y.]] | |||
[[Category: Moreau, N.]] | |||
[[Category: Roos, G.]] | |||
[[Category: Sivignon, A.]] | |||
[[Category: Cell adhesion]] | |||
[[Category: Crohn's disease]] | |||
[[Category: Immunoglobulin]] | |||
[[Category: Thiazole]] | |||
[[Category: Type-1 fimbriae]] | |||
Revision as of 15:40, 10 July 2013
A thiazolyl-mannoside bound to FimH, orthorhombic space group
Template:ABSTRACT PUBMED 23795713
Function
[FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
About this Structure
3zl2 is a 1 chain structure with sequence from Escherichia coli j96. Full crystallographic information is available from OCA.
Reference
- Brument S, Sivignon A, Dumych TI, Moreau N, Roos G, Guerardel Y, Chalopin T, Deniaud D, Bilyy RO, Darfeuille-Michaud A, Bouckaert J, Gouin SG. Thiazolylaminomannosides As Potent Antiadhesives of Type 1 Piliated Escherichia coli Isolated from Crohn's Disease Patients. J Med Chem. 2013 Jun 24. PMID:23795713 doi:10.1021/jm400723n
