4bqm: Difference between revisions
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{{STRUCTURE_4bqm| PDB=4bqm | SCENE= }} | |||
===Crystal structure of human liver-type glutaminase, catalytic domain=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GLSL_HUMAN GLSL_HUMAN]] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.<ref>PMID:20378837</ref> | |||
==About this Structure== | |||
[[4bqm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BQM OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Glutaminase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Ambrosio, A L.B.]] | |||
[[Category: Arrowsmith, C H.]] | |||
[[Category: Bountra, C.]] | |||
[[Category: Burgess-Brown, N.]] | |||
[[Category: Coutandin, D.]] | |||
[[Category: Delft, F von.]] | |||
[[Category: Dias, S M.G.]] | |||
[[Category: Edwards, A.]] | |||
[[Category: Ferreira, I M.]] | |||
[[Category: Froese, S.]] | |||
[[Category: Krojer, T.]] | |||
[[Category: Strain-Damerell, C.]] | |||
[[Category: Vollmar, M.]] | |||
[[Category: Williams, E.]] | |||
[[Category: Yue, W W.]] | |||
[[Category: Hydrolase]] | |||
Revision as of 15:51, 10 July 2013
Crystal structure of human liver-type glutaminase, catalytic domain
Function
[GLSL_HUMAN] Plays an important role in the regulation of glutamine catabolism. Promotes mitochondrial respiration and increases ATP generation in cells by catalyzing the synthesis of glutamate and alpha-ketoglutarate. Increases cellular anti-oxidant function via NADH and glutathione production. May play a role in preventing tumor proliferation.[1]
About this Structure
4bqm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7455-60. doi:, 10.1073/pnas.1001006107. Epub 2010 Apr 8. PMID:20378837 doi:10.1073/pnas.1001006107
