4fzs: Difference between revisions
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{{STRUCTURE_4fzs| PDB=4fzs | SCENE= }} | |||
===Structure of human SNX1 BAR domain=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SNX1_HUMAN SNX1_HUMAN]] May be involved in several stages of intracellular trafficking. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi. Component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2).<ref>PMID:12198132</ref> <ref>PMID:15498486</ref> <ref>PMID:17101778</ref> | |||
==About this Structure== | |||
[[4fzs]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4FZS OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Bhatia, V K.]] | |||
[[Category: Cullen, P J.]] | |||
[[Category: Hurley, J H.]] | |||
[[Category: Kloer, D P.]] | |||
[[Category: Sessions, R B.]] | |||
[[Category: Stamou, D.]] | |||
[[Category: Traer, C J.]] | |||
[[Category: Weering, J R.T van.]] | |||
[[Category: Bar]] | |||
[[Category: Membrane remodeling]] | |||
[[Category: Protein transport]] | |||