Met repressor: Difference between revisions
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[[Image:1mjo.png|left|200px|thumb|EcMR (mutant) complex with corepressor SAM and DNA [[2eyi]]]] | [[Image:1mjo.png|left|200px|thumb|EcMR (mutant) complex with corepressor SAM and DNA [[2eyi]]]] | ||
{{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM and DNA [[1mjo]] }} | {{STRUCTURE_1mjo| PDB=1mjo | SIZE=400| SCENE= |right|CAPTION=EcMR (mutant) complex with corepressor SAM Ca+2 ion and DNA [[1mjo]] }} | ||
Revision as of 08:48, 11 July 2013
Met repressor (MR) interacts with the DNA operator (Met box) repressing methionine synthesis. The corepressor of MR is S-adenosyl methionine (SAM) which is a product of methionine synthesis. Binding of SAM to MR increases the repressor affinity to the DNA thus halting methionine synthesis. For additional details see Joe Granger Methionine Repressor: Escherichia coli.
3D Structures of Met repressor
Updated on 11-July-2013
1cmb – EcMR – Escherichia coli
1mjk – EcMR (mutant)
1cma – EcMR + DNA
1mjm – EcMR (mutant) + DNA
1cmc – EcMR + SAM
1mjl, 1mjp – EcMR (mutant) + SAM
1mj2, 1mjo, 1mjq – EcMR (mutant) + SAM + DNA
