1oe4: Difference between revisions
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{{STRUCTURE_1oe4| PDB=1oe4 | SCENE= }} | {{STRUCTURE_1oe4| PDB=1oe4 | SCENE= }} | ||
===Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase=== | |||
{{ABSTRACT_PUBMED_12820976}} | |||
=== | ==Function== | ||
[[http://www.uniprot.org/uniprot/SMUG1_XENLA SMUG1_XENLA]] Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. No enzymatic activity towards G/T mismatches. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:012820976</ref><references group="xtra"/> | <ref group="xtra">PMID:012820976</ref><references group="xtra"/><references/> | ||
[[Category: Xenopus laevis]] | [[Category: Xenopus laevis]] | ||
[[Category: Pearl, L H.]] | [[Category: Pearl, L H.]] | ||
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[[Category: Dna glycosylase]] | [[Category: Dna glycosylase]] | ||
[[Category: Hydrolase]] | [[Category: Hydrolase]] | ||
[[Category: Hydrolase-complex]] | [[Category: Hydrolase-dna complex]] | ||
[[Category: Single stranded]] | [[Category: Single stranded]] | ||
Revision as of 04:25, 18 July 2013
Xenopus SMUG1, an anti-mutator uracil-DNA Glycosylase
Template:ABSTRACT PUBMED 12820976
Function
[SMUG1_XENLA] Responsible for recognizing base lesions in the genome and initiating base excision DNA repair. Acts as a monofunctional DNA glycosylase specific for uracil (U) residues in DNA and has a preference for single-stranded DNA substrates. No enzymatic activity towards G/T mismatches.
About this Structure
1oe4 is a 4 chain structure with sequence from Xenopus laevis. Full crystallographic information is available from OCA.
See Also
Reference
- Wibley JE, Waters TR, Haushalter K, Verdine GL, Pearl LH. Structure and specificity of the vertebrate anti-mutator uracil-DNA glycosylase SMUG1. Mol Cell. 2003 Jun;11(6):1647-59. PMID:12820976
