4hvx: Difference between revisions
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{{STRUCTURE_4hvx| PDB=4hvx | SCENE= }} | |||
===tRNA-guanine transglycosylase Y106F, C158V mutant in complex with queuine=== | |||
{{ABSTRACT_PUBMED_23704982}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | |||
==About this Structure== | |||
[[4hvx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HVX OCA]. | |||
==See Also== | |||
*[[TRNA-guanine transglycosylase|TRNA-guanine transglycosylase]] | |||
==Reference== | |||
<ref group="xtra">PMID:023704982</ref><references group="xtra"/><references/> | |||
[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]] | |||
[[Category: Biela, I.]] | |||
[[Category: Heine, A.]] | |||
[[Category: Klebe, G.]] | |||
[[Category: Reuter, K.]] | |||
[[Category: Tidten-Luksch, N.]] | |||
[[Category: Bacterial tgt]] | |||
[[Category: Guanine exchange enzyme]] | |||
[[Category: Queuine]] | |||
[[Category: Substrate specificity]] | |||
[[Category: Transferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
Revision as of 04:30, 18 July 2013
tRNA-guanine transglycosylase Y106F, C158V mutant in complex with queuine
Template:ABSTRACT PUBMED 23704982
Function
[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
About this Structure
4hvx is a 1 chain structure with sequence from Zymomonas mobilis subsp. mobilis zm4 = atcc 31821. Full crystallographic information is available from OCA.
See Also
Reference
- Biela I, Tidten-Luksch N, Immekus F, Glinca S, Nguyen TX, Gerber HD, Heine A, Klebe G, Reuter K. Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor. PLoS One. 2013 May 21;8(5):e64240. doi: 10.1371/journal.pone.0064240. Print 2013. PMID:23704982 doi:10.1371/journal.pone.0064240
