4go6: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4go6| PDB=4go6 | SCENE= }} | {{STRUCTURE_4go6| PDB=4go6 | SCENE= }} | ||
===Crystal structure of HCF-1 self-association sequence 1=== | |||
{{ABSTRACT_PUBMED_23045687}} | |||
=== | ==Disease== | ||
[[http://www.uniprot.org/uniprot/HCFC1_HUMAN HCFC1_HUMAN]] X-linked nonsyndromic intellectual deficit. Mental retardation, X-linked 3 (MRX3) [MIM:[http://omim.org/entry/309541 309541]]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:23000143</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/HCFC1_HUMAN HCFC1_HUMAN]] Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.<ref>PMID:10920196</ref> <ref>PMID:9990006</ref> <ref>PMID:10675337</ref> <ref>PMID:10629049</ref> <ref>PMID:10779346</ref> <ref>PMID:12244100</ref> <ref>PMID:14532282</ref> <ref>PMID:12670868</ref> <ref>PMID:15190068</ref> <ref>PMID:16624878</ref> <ref>PMID:17578910</ref> <ref>PMID:20018852</ref> <ref>PMID:20200153</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4go6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GO6 OCA]. | [[4go6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GO6 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023045687</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Herr, W.]] | [[Category: Herr, W.]] | ||
