3zo9: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===The structure of Trehalose Synthase (TreS) of Mycobacterium smegmatis===

~~The entry 3zo9~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/TRES_MYCS2 TRES_MYCS2]] Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Maltose is the preferred substrate. To a lesser extent, also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS plays a key role in the utilization of trehalose for the production of glycogen, and might also function as a sensor and/or regulator of trehalose levels within the cell. Thus, when trehalose levels in the cell become dangerously low, TreS can expedite the conversion of glycogen to maltose via its amylase activity and then convert the maltose to trehalose; but this enzyme also can expedite or promote the conversion of trehalose to glycogen when cytoplasmic trehalose levels become too high. Is also able to catalyze the hydrolytic cleavage of alpha-aryl glucosides, as well as alpha-glucosyl fluoride in vitro.<ref>PMID:15511231</ref> <ref>PMID:18505459</ref> <ref>PMID:20118231</ref> <ref>PMID:21840994</ref>

~~Authors~~: ~~Caner, S~~.~~, Nguyen, N~~.~~, Aguda, A~~.~~, Zhang, R., Pan, Y.T., Withers, S~~.G.~~, Brayer, G~~.D.

==About this Structure==

[[3zo9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZO9 OCA].

~~Description~~: ~~Novel Active Site and Inhibition Sites Identified in Trehalose Synthase~~

==Reference==

[[Category: Mycobacterium smegmatis]]

[[Category: Aguda, A.]]

[[Category: Brayer, G D.]]

[[Category: Caner, S.]]

[[Category: Nguyen, N.]]

[[Category: Pan, Y T.]]

[[Category: Withers, S G.]]

[[Category: Zhang, R.]]

[[Category: Drug design]]

[[Category: Glycohydrolase]]

[[Category: Hydrolase]]

[[Category: Tuberculosis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_3zo9|  PDB=3zo9  |  SCENE=  }}
+===The structure of Trehalose Synthase (TreS) of Mycobacterium smegmatis===
+{{ABSTRACT_PUBMED_23735230}}
-The entry 3zo9 is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/TRES_MYCS2 TRES_MYCS2]] Catalyzes the reversible interconversion of maltose and trehalose by transglucosylation. Maltose is the preferred substrate. To a lesser extent, also displays amylase activity, catalyzing the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in glycogen and maltooligosaccharides such as maltoheptaose, to produce maltose which then can be converted to trehalose. TreS plays a key role in the utilization of trehalose for the production of glycogen, and might also function as a sensor and/or regulator of trehalose levels within the cell. Thus, when trehalose levels in the cell become dangerously low, TreS can expedite the conversion of glycogen to maltose via its amylase activity and then convert the maltose to trehalose; but this enzyme also can expedite or promote the conversion of trehalose to glycogen when cytoplasmic trehalose levels become too high. Is also able to catalyze the hydrolytic cleavage of alpha-aryl glucosides, as well as alpha-glucosyl fluoride in vitro.<ref>PMID:15511231</ref> <ref>PMID:18505459</ref> <ref>PMID:20118231</ref> <ref>PMID:21840994</ref>
-Authors: Caner, S., Nguyen, N., Aguda, A., Zhang, R., Pan, Y.T., Withers, S.G., Brayer, G.D.
+==About this Structure==
+[[3zo9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_smegmatis Mycobacterium smegmatis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZO9 OCA].
-Description: Novel Active Site and Inhibition Sites Identified in Trehalose Synthase
+==Reference==
+<ref group="xtra">PMID:023735230</ref><references group="xtra"/><references/>
+[[Category: Mycobacterium smegmatis]]
+[[Category: Aguda, A.]]
+[[Category: Brayer, G D.]]
+[[Category: Caner, S.]]
+[[Category: Nguyen, N.]]
+[[Category: Pan, Y T.]]
+[[Category: Withers, S G.]]
+[[Category: Zhang, R.]]
+[[Category: Drug design]]
+[[Category: Glycohydrolase]]
+[[Category: Hydrolase]]
+[[Category: Tuberculosis]]