4bvb: Difference between revisions
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{{STRUCTURE_4bvb| PDB=4bvb | SCENE= }} | |||
===CRYSTAL STRUCTURE OF HUMAN SIRT3 IN COMPLEX WITH THE INHIBITOR EX-527 AND ADP-RIBOSE=== | |||
{{ABSTRACT_PUBMED_23840057}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref> | |||
==About this Structure== | |||
[[4bvb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BVB OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023840057</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Gertz, M.]] | |||
[[Category: Steegborn, C.]] | |||
[[Category: Weyand, M.]] | |||
[[Category: Adp-ribose]] | |||
[[Category: Hydrolase]] | |||
[[Category: Inhibitor complex]] | |||
[[Category: Nad-dependent deacetylase]] | |||