2iqg: Difference between revisions
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==Overview== | ==Overview== | ||
The design and synthesis of a novel series of potent and cell permeable | The design and synthesis of a novel series of potent and cell permeable peptidomimetic inhibitors of the human beta-secretase (BACE) are described. These inhibitors feature a hydroxyethyl secondary amine isostere and a novel aromatic ring replacement for the C-terminus. The crystal structure of BACE in complex with this hydroxyethyl secondary amine isostere inhibitor is also presented. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Benson, T | [[Category: Benson, T E.]] | ||
[[Category: Emmons, T | [[Category: Emmons, T L.]] | ||
[[Category: Prince, D | [[Category: Prince, D B.]] | ||
[[Category: Tomasselli, A | [[Category: Tomasselli, A G.]] | ||
[[Category: Woods, D | [[Category: Woods, D D.]] | ||
[[Category: F2I]] | [[Category: F2I]] | ||
[[Category: protein-inhibitor complex]] | [[Category: protein-inhibitor complex]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:55:04 2008'' | ||
